Fri Sep 23 2022

26 articles - From Friday Sep 16 2022 to Friday Sep 23 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Nephrol Dial Transplant

Impact of incremental initiation of haemodialysis on mortality: a systematic review and meta-analysis.

Incremental initiation of haemodialysis does not confer greater risk of mortality compared to standard treatment. Hospitalisation may be reduced and costs are less.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Peritoneal Dialysis-Associated Peritonitis Trends Using Medicare Claims Data, 2013-2017.

PD-associated peritonitis rates decline over time and were lower among older patients. A claims-based approach offers a promising framework for the study of PD-associated peritonitis.

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Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.

Plasma sTNFR1 and sTNFR2 measured 3 months after discharge were independently associated with clinical events, regardless of AKI status during the index admission. sTNFR1 and sTNFR2 may assist with the risk stratification of patients during follow-up.

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Clin J Am Soc Nephrol

Comparison of 2021 CKD-EPI Equations for Estimating Racial Differences in Preemptive Waitlisting for Kidney Transplantation.

Using bootstrapping, the ratio of the time ratio of the models using the creatinine versus creatinine-cystatin C equation was statistically significantly different (ratio of the time ratios = 1.31 with 95% confidence interval, 1.06 to 1.62). Use of the 2021 creatinine-based CKD-EPI equation to determine preemptive waitlist eligibility reduced racial differences in preemptive wait time accrual more than use of the creatinine-cystatin C2021 CKD-EPI equation within a theoretical context.

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Implementation and Effectiveness of a Learning Collaborative to Improve Palliative Care for Seriously Ill Hemodialysis Patients.

A learning collaborative for hemodialysis centers spanning the coronavirus disease 2019 pandemic was associated with adoption of serious illness screening and goals of care discussions as well as improved documentation of advance care planning for seriously ill patients. Clinical trial registry name and registration number Pathways Project Kidney Supportive Care, NCT04125537.

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Point-of-Care Ultrasound Training during Nephrology Fellowship: A National Survey of Fellows and Program Directors.

Despite high trainee and faculty interest in POCUS, the majority of current nephrology fellows are not receiving POCUS training. Hands-on training guided by an instructor is highly valued, yet availability of adequately trained instructors remains a barrier to program development. Podcast This article contains a podcast at

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J Am Soc Nephrol

Genetic variants of the COL4A3, COL4A4, and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients.

variant detection is essential in evaluating patients with sporadic IgAN with tGBM lesions.

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Kidney Int

Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis.

Interestingly, we found that the human kidney-derived hematopoietic stem cells took up long-term residence in the recipient's bone marrow and gradually replaced their host counterparts, leading to blood type conversion and full donor chimerism of both lymphoid and myeloid lineages. Thus, our findings highlight the existence of human kidney-derived hematopoietic stem cells with a self-renewal ability able to support multilineage hematopoiesis.

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In vitro and In vivo evidence that the switch from calcineurin to mTOR-inhibitors may be a strategy for immunosuppression in Epstein-Barr-Virus-associated post-transplant lymphoproliferative disorder.

Overall, our study provides a basis for the clinical decision for the modification and reduction of immunosuppression and adds information to the complex balance of maintaining anti-viral immunity while preventing acute rejection. Thus, an immunosuppressive regime based on mTOR-inhibition and reduced or withdrawn calcineurin inhibitors could be a promising strategy for patients with increased risk of or manifested EBV-associated post-transplant lymphoproliferative disorder.

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The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease.

By deconvolution analysis of RNAseq samples and by immunostaining of biopsies from patients with DKD, we further confirmed a differential expression of select genes in specific macrophage subsets essentially recapitulating the studies in mice. Thus, our study provides a comprehensive analysis of macrophage transcriptomic profiles in early DKD that underscores the dynamic macrophage phenotypes in disease progression.

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Nephrol Dial Transplant

Cadmium, active smoking and renal function deterioration in patients with type 2 diabetes.

Active smoking is associated with progressive kidney disease in T2D. The association between cadmium concentration and renal function deterioration is for a large part determined by smoking status. Extensive assessment of smoking status may be useful in patients with T2D at high risk of kidney damage.

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Coronary artery calcium and risk of chronic kidney disease in young and middle-aged adults.

Methods A cohort study of 113 171 Korean adults (mean age, 40.6 years) without CKD and proteinuria at baseline, who underwent a cardiac tomography estimation of CACS during health screening examinations, was performed (median follow-up: 4.2 years). The outcome was CKD, defined as an estimated glomerular filtration rate (eGFR) 0 appear to have an increased risk of CKD and may benefit from preventive measures to reduce CKD risk.

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Effect of the phosphate binder sucroferric oxyhydroxide in dialysis patients on endogenous calciprotein particles, inflammation, and vascular cells.

High-dose SO reduced endogenous CPP formation in dialysis patients and yielded serum with attenuated pro-calcific and inflammatory effects in vitro.

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Hippocampal subfield morphology in regular hemodialysis patients.

We found smaller hippocampal subfield volumes in hemodialysis patients, which were associated with impaired cognition, supporting their role in memory disturbance in the hemodialysis population. However, multiple clinical factors may have confounded the results, and therefore, the interpretation of these results needs to be cautious.

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Microbiology and outcomes of polymicrobial peritonitis associated with peritoneal dialysis: a register-based cohort study from the French Language Peritoneal Dialysis Registry (RDPLF).

Isolation of enteric pathogens, rather than the polymicrobial character of the peritonitis, is associated with poorer outcomes.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Cannabinoid Signaling in the Diabetic Proximal Tubule: Of Mice and Men.

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Clin J Am Soc Nephrol

Incorporating Training in POCUS in Nephrology Fellowship Curriculum.

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Palliative Care for Hemodialysis Patients?

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Reducing Racial Disparities in Access to Transplant in the United States: One Step at a Time.

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Nat Rev Nephrol

Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease.

However, major clinical guidelines are not consistent in their incorporation of CKD measures for CVD risk prediction. Mitigating CVD risk in patients with CKD effectively requires multidisciplinary care that involves nephrologists, cardiologists and other health professionals, as well as further work to address current research and implementation gaps.

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Epidemiology of peritoneal dialysis outcomes.

PD outcomes have been improving over time but with great variability, driven by individual and system-level inequities and by centre effects; this variation is exacerbated by a lack of standardized outcome definitions. Potential strategies for outcome improvement include enhanced standardization, monitoring and reporting of PD outcomes, and the implementation of continuous quality improvement programmes and of PD-specific interventions, such as incremental PD, the use of biocompatible PD solutions and remote PD monitoring.

Pubmed   Journal   ReadQx   PMC

Regulation of nephron progenitor cell lifespan and nephron endowment.

In humans, a tenfold variation in nephron endowment between individuals contributes to differences in susceptibility to kidney disease; however, the mechanisms underlying this variation are not yet clear. Salient advances in our understanding of environmental inputs, and of intrinsic molecular mechanisms that contribute to the regulation of cessation timing or nephron progenitor cell exhaustion, have the potential to inform interventions to enhance nephron endowment and improve lifelong kidney health for susceptible individuals.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Clin J Am Soc Nephrol

Obesity in CKD: A Promising Path Forward.

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Kidney Int

COVID-19 vaccine effectiveness in patients with non-dialysis dependent chronic kidney diseases; findings from a population based observational study from British Columbia, Canada.

Pubmed   Journal   ReadQx   PMC

Nat Rev Nephrol

Nephrology and women's health post-Roe v. Wade: we must do better.

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Targeting perivascular S1P attenuates inflammation.

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Letters&Replies

Letters to the editors and authors’ replies